Bovine Spongiform Encephalopathy: The BSE Dilemma
Clarence J. Gibbs
Springer, Jan 1, 1996 - Medical - 413 pages
The very first international working discussion on slow infections of the nervous system was entitled "Slow, Latent, and Temperate Virus Infec tions" and was held at the National Institutes of Health (NIH) in December 1964. The primary impetus was the discovery and investigation of kuru in New Guinea by D. Carleton Gajdusek, M. D. This working discussion brought together investigators in human and veterinary medicine, virolo gists, microbiologists, and neuropathologists actively engaged in laboratory work with viruses that illustrated properties of latency, masking, slowness, or temperateness, with emphasis on subacute and chronic neurologic dis eases of unknown etiology. In the Preface to the monograph of published papers presented at the working discussion, Gajdusek and Gibbs wrote the following: After microbiology had given solution to the etiology of most acute infections of the central nervous system and after fungi and bacteria had been incriminated in impor tant chronic disorders of the nervous system such as torula and tuberculosis men ingitis, we have been left, in neurology, with a wide range of subacute and chronic affections of the central nervous systems of unknown etiology. Some of these diseases, still listed as idiopathic, are among the most prevalent afflictions of the central nervous system. Many others with familial patterns of occurrence do not yet have their basic pathogenesis or underlying metabolic defect elucidated, although we tend to think of them as genetically mediated.
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The Potential Risk to Humans of Amyloids in Animals
Bovine Spongiform Encephalopathy Distribution
Preliminary Observations on the Pathogenesis
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Acad Sci USA acid affected allele amyloid plaques amyloidoses animals antibody bioassay Bovine spongiform encephalopathy cells chronic wasting disease clinical signs codon confirmed cows Creutzfeldt-Jakob disease dams detected epidemic epidemiologic experimental exposure feed fibrils Fraser H Gajdusek DC Gen Virol genetic genotype Gibbs CJ Jr Hadlow WJ human incidence incubation period infectivity inoculated intracerebral Kimberlin RH Laboratory mice molecular mouse mutation Natl Acad Sci natural scrapie nervous system neurologic neurons nonambulatory cattle occurred oral pathogenesis prion diseases prion protein Prnp Proc Natl Acad progeny PrP gene PrP-res PrP-sen PrPc PrPSc Prusiner SB replication risk ruminant scrapie agent scrapie strain scrapie-associated scrapie-infected scrapie-like sheep and goats sheep scrapie species barrier spleen sporadic CJD strain of scrapie studies Suffolk sheep surveillance Table tion tissues transgenic transmissible mink encephalopathy Transmissible spongiform encephalopathies transmission of scrapie United Kingdom Veterinary virus Wilesmith JW