Bovine Spongiform Encephalopathy: The BSE DilemmaThe very first international working discussion on slow infections of the nervous system was entitled "Slow, Latent, and Temperate Virus Infec tions" and was held at the National Institutes of Health (NIH) in December 1964. The primary impetus was the discovery and investigation of kuru in New Guinea by D. Carleton Gajdusek, M. D. This working discussion brought together investigators in human and veterinary medicine, virolo gists, microbiologists, and neuropathologists actively engaged in laboratory work with viruses that illustrated properties of latency, masking, slowness, or temperateness, with emphasis on subacute and chronic neurologic dis eases of unknown etiology. In the Preface to the monograph of published papers presented at the working discussion, Gajdusek and Gibbs wrote the following: After microbiology had given solution to the etiology of most acute infections of the central nervous system and after fungi and bacteria had been incriminated in impor tant chronic disorders of the nervous system such as torula and tuberculosis men ingitis, we have been left, in neurology, with a wide range of subacute and chronic affections of the central nervous systems of unknown etiology. Some of these diseases, still listed as idiopathic, are among the most prevalent afflictions of the central nervous system. Many others with familial patterns of occurrence do not yet have their basic pathogenesis or underlying metabolic defect elucidated, although we tend to think of them as genetically mediated. |
Contents
The Potential Risk to Humans of Amyloids in Animals | 1 |
Bovine Spongiform Encephalopathy Distribution | 11 |
Preliminary Observations on the Pathogenesis | 28 |
Copyright | |
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Acad Sci USA acid affected allele amyloid plaques amyloidoses animals antibody bioassay Bovine spongiform encephalopathy calves cells chronic wasting disease clinical signs codon cows Creutzfeldt-Jakob disease dams detected Dickinson epidemic epidemiologic evidence experimental exposure feed fibrils Fraser H Gajdusek DC Gen Virol genetic genotype Gibbs CJ Jr Hadlow WJ hamster brain human incidence incubation period infectivity inoculated intracerebral Kimberlin RH molecular months p.i. mouse mutation Natl Acad Sci natural scrapie neurologic neurons nonambulatory cattle occurred oral pathogenesis prion diseases prion protein Prnp Proc Natl Acad progeny PrP gene PrP-res PrP-sen PrPC PrPsc Prusiner SB replication risk ruminant scrapie agent scrapie strain scrapie-associated scrapie-infected sheep and goats sheep scrapie species barrier spleen sporadic CJD strain of scrapie studies Suffolk sheep surveillance Syrian hamsters Table tion tissue transgenic transmissible mink encephalopathy Transmissible spongiform encephalopathies transmission of scrapie United Kingdom virus Wilesmith JW
References to this book
International Review of Neurobiology Ronald J. Bradley,R. Adron R. Harris,Peter Jenner Limited preview - 2005 |
International Review of Neurobiology Ronald J. Bradley,R. Adron R. Harris,Peter Jenner Limited preview - 2005 |