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200 msec Figure adjusted amplitude analog computer anesthesia machine anesthetic depth arterial concentration autocorrelation Beduhn Bickford breathing frequency cardiac output change in reference clock interval concentration of halothane control system criterion function crosscorrelation decrease depth of anesthesia determine the impulse endotracheal tube flow of halothane fractional partial pressure Fukui gradient grey matter partial halothane concentration heart rate hybrid computer model impulse response increased integral l/min level of anesthesia MAP in mmHg matter partial pressure maximum length sequence mean arterial pressure ml/sec muscle relaxants parameter estimation program partition coefficient patient PHIX PHIX PHIX physically-based model PI controller PRBS method PRBS of length PRBS signal pressure of halothane pressure-flow model reference pressure resistance response in Fig responses of mean saturation limited servo-anesthesia system shown in Fig spectral edge frequency steepest descent step change system output Tidal volume transfer function transfer function model transport model uptake and distribution