The Evidence Base of Clinical Diagnosis: Theory and Methods of Diagnostic Research

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J. André Knottnerus, Frank Buntinx
John Wiley & Sons, Aug 26, 2011 - Medical - 320 pages
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This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The Evidence Base of Clinical Diagnosis has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data.

With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.


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List of Contributors
fare better in their ultimate health outcomes than similar patients
the reference standard
the randomized
Designing studies to ensure that estimates of test
Data analysis
Producing and using clinical prediction rules
Clinical problem solving and diagnostic decision
Errors in probability estimation
Methodological guidelines
Improving test ordering and its diagnostic cost
overview of evaluation strategy

Continuous tests and their dichotomization and trichotomization
Problems shared by all methods
Standards for reporting on diagnostic accuracy

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About the author (2011)

Andre Knottnerus, Professor of General Practice, Maastricht University. He is involved in the Cochrane movement for drawing up tools for accurate diagnostic testing

Frank Buntinx, Professor, Department of Public Health, Leuven University. He is one time chair of the Cochrane Collaboration Diagnostic and Screening Tests Working Group

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