The Evidence Base of Clinical Diagnosis: Theory and Methods of Diagnostic Research

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J. André Knottnerus, Frank Buntinx
John Wiley & Sons, Aug 26, 2011 - Medical - 320 pages
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This unique book presents a framework for the strategy andmethodology of diagnostic research, in relation to its relevancefor practice. Now in its second edition The Evidence Base ofClinical Diagnosis has been fully revised and extended with newchapters covering the STARD guidelines (STAndards for the Reportingof Diagnostic accuracy studies) and the multivariable analysis ofdiagnostic data.

With contributions from leading international experts inevidence-based medicine, this book is an indispensable guide on howto conduct and interpret studies in clinical diagnosis. It willserve as a valuable resource for all investigators who want toembark on diagnostic research and for clinicians, practitioners andstudents who want to learn more about its principles and therelevant methodological options available.


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List of Contributors
fare better in their ultimate health outcomes than similar patients
the reference standard
the randomized
Designing studies to ensure that estimates of test
Data analysis
Producing and using clinical prediction rules
Clinical problem solving and diagnostic decision
Errors in probability estimation
Methodological guidelines
Improving test ordering and its diagnostic cost
overview of evaluation strategy

Continuous tests and their dichotomization and trichotomization
Problems shared by all methods
Standards for reporting on diagnostic accuracy

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About the author (2011)

Andre Knottnerus, Professor of General Practice,Maastricht University. He is involved in the Cochrane movement fordrawing up tools for accurate diagnostic testing

Frank Buntinx, Professor, Department of Public Health,Leuven University. He is one time chair of the CochraneCollaboration Diagnostic and Screening Tests Working Group

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