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Reduction of NADPHCytochrome P450 Reductase
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activity addition amino acid analysis Arch Biochem Biophys bile acids binding Biochem Biophys Res Biochemistry Biol Chem catalyzed cDNA cells changes characterization chemical cholesterol chrome cloned complex compounds containing Coon cultured cyto cytochrome P450 decrease dependent determined drug effect electron enzyme et al evidence expression formation forms forms of cytochrome function gene genetic Gonzalez FJ Guengerich heme hepatic hormone human hydroxylase hydroxylation identified important increased indicated induced inhibition interaction involved isolated isozymes levels lipid liver microsomes lung male mammalian mechanism membrane metabolism microsomal cytochrome mitochondrial molecular monooxygenase mRNA mutation NADPH Nebert observed oxidation oxygen Pharmacol phenobarbital plant position presence properties protein purified rabbit rat liver reaction recently reconstituted reduction region regulation reported residues responsible role sequence showed shown similar specific steroid structure studies substrate suggested Table tissues Waxman