Handbook of Heterogeneous Catalytic Hydrogenation for Organic Synthesis
A complete guide to the most important reduction method in organic synthesis
The most comprehensive reference in the field, Handbook of Heterogeneous Catalytic Hydrogenation for Organic Synthesis provides synthetic chemists and chemical engineers in fine chemicals and pharmaceuticals with detailed experimental guidelines for heterogeneous catalytic hydrogenation. Organized by functional groups for ready reference and featuring detailed examples of hundreds of reactions, this handbook covers hydrogenations of alkenes, alkynes, aldehydes and ketones, nitriles, imines, nitro and nitroso compounds, carboxylic acids and esters, and aromatic and heterocyclic compounds. In addition, coverage includes the preparation of amines by reductive alkylation and the hydrogenolysis of a variety of compounds. Examples of hydrogenation of functional groups and reaction pathways are illustrated with numerous equations and schemes.
Practitioners will appreciate the plenitude of experimental details given for most of the reactions selected, including amounts of reagents and catalysts, reaction temperatures, hydrogen pressures, and reaction times. They will also find helpful the more than one hundred tables included throughout the book detailing the effects of key factors governing rate and selectivity, such as compound structure, the nature of catalysts and supports, and the nature of solvents. Researchers will benefit from the introductory chapters covering an array of hydrogenation catalysts, including nickel, cobalt, copper, iron, platinum group metals, rhenium, and other oxide and sulfide catalysts, as well as reactors and reaction conditions.
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Reactors and Reaction Conditions
Hydrogenation of Alkenes
Hydrogenation of Alkynes
11 other sections not shown
acetic acid AcOH active addition Adkins alcohol aldehydes alkaline alkyl alloy amino ammonia aqueous aromatic atm H2 atmospheric pressure benzene benzyl Bull carbon Chem Chem Soc Chim chloride chloroplatinic acid cis isomer cobalt compounds copper-chromium oxide corresponding cyclohexane derivatives dioxane double bond drogenation esters ethanol ether ethyl formation g Raney genation high yields hydrazine hydro hydrogen pressure hydrogenated to give hydrogenolysis intermediate isomerization ketones Lindlar catalyst MeOH mixture ml EtOH mmol MPa H2 Ni-kieselguhr nickel catalysts Nishimura nitriles nitro nitrobenzene obtained oxime palladium catalysts Pd-C phenol platinum catalysts platinum metals prepared presence primary amine Pt oxide Pt-C pyridine quantitative quinoline rate of hydrogenation ratio reaction reduction Reprinted with permission Rh-C rhodium room temperature ruthenium saturated Scheme secondary amine selective hydrogenation shown in eq small amount sodium hydroxide solution solvent substrate sulfide temperature and atmospheric Tetrahedron tion trans unsaturated uptake