MPTP, a Neurotoxin Producing a Parkinsonian SyndromeSanford P. Markey |
Contents
A Review | 9 |
The MPTPTreated Monkey Model of Parkinsons Disease | 23 |
MPTP and MPP+ Induced Neurotoxicity in Rodents and | 45 |
Copyright | |
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Common terms and phrases
action activity administration amine analogs animals appears behavioral binding Biochem body brain catecholamine cause cells changes Chronic clinical compacta compared compound concentrations containing decrease depletion dopa dopamine dopamine neurons dopaminergic dose drug effects of MPTP enzyme evidence experiments findings human increase indicate induced inhibition inhibitors injection involved L-DOPA Langston levels loss MAO-B Markey measured mechanism metabolism metabolite METHODS mg/kg mice midbrain monkey monoamine oxidase motor mouse movement MPDP+ MPP+ MPTP-induced nerve neurons neurotoxic neurotoxin nigrostriatal normal observed occur oxidation pargyline Parkinson's disease parkinsonian parkinsonism patients possible potential preparations present Press primates produced protective reaction reduced regions reported response Science seen selective severe showed shown significant similar species striatal striatal dopamine striatum studies substantia nigra substrate suggest SYNDROME Table tion tissue toxicity treated treatment uptake values