Genetics of Obesity Syndromes
Oxford University Press, Aug 29, 2008 - Medical - 304 pages
Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients. The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.
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abnormalities activity adiposity adults affected Albright hereditary osteodystrophy allele ALMS1 Alström syndrome associated autosomal Badano Bardet-Biedl syndrome basal BBS proteins BBS1 BBS2 BBS4 BBS6 behavior BFLS brachydactyly cause cells chromosome cilia clinical Cohen syndrome Cohen syndrome patients congenital convertases corticotropin defects deletion developmental delay diabetes disease disorders drome encoding endocrine Exon Exon 1A expression families Farooqi Figure function genomic GNAS GNAS1 growth hormone heterozygous Hum Genet Hum Mol Genet human hyperphagia hypogonadism hypothalamic identified impaired increased individuals inheritance insulin intraflagellar transport kidney Kivitie-Kallio leptin leptin deficiency leptin receptor levels maternal MC4R melanocortin mental retardation metabolic mice microcephaly missense molecular Nat Genet necdin neurons normal obesity Pediatr peptides phenotype PHP Ia pituitary plasma POMC POMC gene PPHP Prader-Willi syndrome pro-opiomelanocortin prohormone proinsulin pseudohypoparathyroidism region regulation renal reported result retinal severe obesity short stature tion tissues transcript X-linked XLAS