Molecular and Biochemical ToxicologyRobert C. Smart, Ernest Hodgson An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:
Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects. |
Contents
Regulation | 2 |
Toxicogenomics | |
Proteomics | |
Metabolomics | |
lmmunochemical Techniques ln Toxicology | |
Cellular Techniques | |
Phase 1 Metabolism of Toxicants | |
Suggested Reading | |
Metals | |
DNA Damage and Mutagenesis | |
DNA Repair | |
Carcinogenesis | |
Genetic Toxicology | |
Molecular Epidemiology and Genetic | |
Respiratoq Toxicity | |
Hepatotoxicity | |
Phase llConiugation of Toxicants | |
Regulation and Polymorphisms in Phase II | |
Developmental Effects on Xenobiotic | |
Structure Mechanism and Regulation | |
Cellular Transport and Elimination | |
Mechanisms of Cell Death | |
Mitochondrial Dysfunction | |
GlutathioneDependent Mechanisms | |
ToxicantReceptor Interactions | |
Reactive Ox en Reactive Metabolites | |