Foye's Principles of Medicinal Chemistry
Thomas L. Lemke, David A. Williams
Lippincott Williams & Wilkins, Jan 24, 2012 - Medical - 1520 pages
Acclaimed by students and instructors alike, Foye's Principles of Medicinal Chemistry is now in its Seventh Edition, featuring updated chapters plus new material that meets the needs of today's medicinal chemistry courses. This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy. All the chapters have been written by an international team of respected researchers and academicians. Careful editing ensures thoroughness, a consistent style and format, and easy navigation throughout the text.
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DRUG RECEPTORS AFFECTING NEUROTRANSMISSION AND ENZYMES AS CATALYTIC RECEPTORS ...
DISEASE STATE MANAGEMENT
APPENDIX A pKa and CLogP Values for Some Drugs and pKa Values for Miscellaneous Organic Acids and Bases ...
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5-HT1A receptor 5-HT2C receptors absorption acetylcholine action activity administration affinity agents agonists amine amino acid anesthetic antagonists antipsychotic aromatic atom benzodiazepines binding bioavailability biologic bond brain cancer catalyzed cells CH3 CH3 channel Chem chemical clinical clozapine compounds conjugation decrease diazepam disease disorders dopamine dose drug elimination enantiomers enzyme ester excreted factors FIGURE functional groups GABA GABAA receptor gene glucuronide glutamate GPCRs half-life hepatic hepatotoxicity hormone human hydrolysis hydroxylation increase inhibition inhibitors intestinal isoforms kinase l-DOPA ligands lipophilic liver mechanism membrane metabolism metabolites molecular molecule muscarinic muscle natural products neurons neurotransmitter norepinephrine oral oxidation P-gp pathway patients peptide Pharmaceutical pharmacokinetics Pharmacol pharmacologic phenobarbital phenytoin plasma concentration potential protein reactions reactive recep renal response result role seizures selective serotonin side effects solubility specific structure studies substrates subtypes subunit target therapeutic therapy tion tissue toxicity transport treatment urine xenobiotics zaleplon zolpidem