Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals

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Marc E. de Broe, George A. Porter, William M. Bennett, G.A. Verpooten
Springer Science & Business Media, May 8, 2007 - Medical - 712 pages
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To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
 

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Contents

Clinical relevance
3
Renal handling of drugs and xenobiotics
21
Pharmacovigilance
47
Cellular mechanisms of nephrotoxicity
65
Animal models for the assessment of acute renal dysfunction and injury
79
contribution to the understanding
115
Aminoglycosides and vancomycin
151
pyrimethamine dapsone quinolones
223
Mercuryinduced renal effects
531
Hydrocarbons siliconcontaining compounds and pesticides
545
Lithiuminduced renal effects
559
Aristolochic acid nephropathy after Chinese herb remedies
579
Balkan endemic nephropathy
587
Nephrotoxins in Africa
603
Paraphenylene diamine hair dye poisoning
611
Urinary biomarkers and nephrotoxicity 621
620

06
230
E De Broe G A Porter W M Bennett G A Verpooten Editors Clinical Nephrotoxins 2nd Ed 77114
248
Lead nephropathy
495
Cadmiuminduced renal effects
507
Pharmacological aspects of nephrotoxicity
657
Drug dosage in renal failure
667
LIST OF ABBREVIATIONS 681
680
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