Epstein-Barr Virus

Erle S. Robertson

Horizon Scientific Press, 2005 - Medical - 770 pages

Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man. It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), certain forms of T-cell lymphoma, and some epithelial tumors (e.g. nasopharyngeal carcinomas and gastric carcinomas). The virus has the unique ability to persist in the infected, apparently healthy host for life. Understanding the molecular interaction between EBV and its human host, the ability of the virus to modulate the host immune system, its ability to hide in B-memory cells and factors that trigger viral reactivation are fundamental to understanding the cellular and molecular pathogenesis of the virus. This is critical for the development of strategies for the prevention and control of infection and disease. In this book, world renowned EBV experts provide a critical and comprehensive review of every aspect of this important virus. By integrating genetic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the molecular and cellular interaction between EBV and its human host have emerged. Topics covered include: discovery, history and seroepidemiology, EBV and the immune response, EBV genetics, EBV infection and persistence, latency, lytic proteins and reactivation control, vaccine approaches, animal models, and the future of EBV studies. This is essential reading for all EBV virologists as well as clinical and research scientists working on oncogenic viruses.

Contents

• The Origins of EB V Research Discovery and Characterization of the Virus: 1
• The Early Days of EpsteinBarr Virus Research The Henle Years: 15
• EBV and the Tumor Virus Context: 23
• Sero Epidemiology of EBV and Associated Malignancies: 29
• Clinical Aspects of EpsteinBarr Virus Infection: 35
• EpsteinBarr Virus and Oral Malignancies: 55
• Epstein Barr Virus in the Pathogenesis of NPC: 71
• Hodgkins Lymphoma Molecular Pathogenesis and the Contribution: 93
• Endemic Burkitts Lymphoma: 113
• EBV and Breast Cancer Questions and Implications: 139
• EpsteinBarr Virus and Gastric Cancers: 157
• EpsteinBarr Virus Invasion and Metastasis: 171
• Immune Response and Evasion in the HostEBV Interaction: 197
• EBV Induces an Endogenous Superantigen Implications for Pathogenesis: 233
• EpsteinBarr Virus Genome: 263
• Strategies for Reverse Genetic Analysis of EBV: 289
• EBV Persistence and Latent Infection In Vivo: 309
• Probiotics and Emerging Applications 2004: 311
• EBV Entry and Epithelial Infection: 359
• The Plasmid Replicon of EBV An Element That Underlies: 379
• EBV Latency: 403
• Role of EBERs: 429
• EBNA2 Transcription Regulation in EBV Latency: 439
• Chapter 23: 463
• EpsteinBarr Virus and the Cell Cycle: 501
• Function of Latent Membrane Protein 2A: 533
• EpsteinBarr Virus Latent Infection Membrane Protein One: 553
• EBV Lytic Infection: 571
• Biological Role of BARF1 Gene Encoded by EpsteinBarr Virus: 613
• Posttranscriptional Gene Regulation by EBV SM Protein: 631
• Developing Vaccines Against EBVAssociated Diseases: 651
• Epstein Barr Virus Cell Based Immunotherapeutics: 669
• Animal Models: 682
• EpsteinBarr Virus Related Lymphocryptoviruses of Old and New World: 691
• EpsteinBarr Virus Summary Conclusions and a Forward Look: 711
• Index: 755
• Colour Plates: 773

Bibliographic information

• Title: Epstein-Barr Virus
• Editor: Erle S. Robertson
• Edition: illustrated
• Publisher: Horizon Scientific Press, 2005
• ISBN: 1904455034, 9781904455035
• Length: 770 pages
• Subjects: Medical / Immunology; Medical / Infectious Diseases; Science / Life Sciences / Microbiology; Science / Life Sciences / Molecular Biology