Epstein-Barr Virus

Front Cover
Erle S. Robertson
Horizon Scientific Press, 2005 - Medical - 770 pages
1 Review
Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man. It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), certain forms of T-cell lymphoma, and some epithelial tumors (e.g. nasopharyngeal carcinomas and gastric carcinomas). The virus has the unique ability to persist in the infected, apparently healthy host for life. Understanding the molecular interaction between EBV and its human host, the ability of the virus to modulate the host immune system, its ability to hide in B-memory cells and factors that trigger viral reactivation are fundamental to understanding the cellular and molecular pathogenesis of the virus. This is critical for the development of strategies for the prevention and control of infection and disease. In this book, world renowned EBV experts provide a critical and comprehensive review of every aspect of this important virus. By integrating genetic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the molecular and cellular interaction between EBV and its human host have emerged. Topics covered include: discovery, history and seroepidemiology, EBV and the immune response, EBV genetics, EBV infection and persistence, latency, lytic proteins and reactivation control, vaccine approaches, animal models, and the future of EBV studies. This is essential reading for all EBV virologists as well as clinical and research scientists working on oncogenic viruses.
 

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Contents

The Origins of EB V Research Discovery and Characterization of the Virus
1
The Early Days of EpsteinBarr Virus Research The Henle Years
15
EBV and the Tumor Virus Context
23
Sero Epidemiology of EBV and Associated Malignancies
29
Clinical Aspects of EpsteinBarr Virus Infection
35
EpsteinBarr Virus and Oral Malignancies
55
Epstein Barr Virus in the Pathogenesis of NPC
71
Hodgkins Lymphoma Molecular Pathogenesis and the Contribution
93
The Plasmid Replicon of EBV An Element That Underlies
379
EBV Latency
403
Role of EBERs
429
EBNA2 Transcription Regulation in EBV Latency
439
Chapter 23
463
EpsteinBarr Virus and the Cell Cycle
501
Function of Latent Membrane Protein 2A
533
EpsteinBarr Virus Latent Infection Membrane Protein One
553

Endemic Burkitts Lymphoma
113
EBV and Breast Cancer Questions and Implications
139
EpsteinBarr Virus and Gastric Cancers
157
EpsteinBarr Virus Invasion and Metastasis
171
Immune Response and Evasion in the HostEBV Interaction
197
EBV Induces an Endogenous Superantigen Implications for Pathogenesis
233
EpsteinBarr Virus Genome
263
Strategies for Reverse Genetic Analysis of EBV
289
EBV Persistence and Latent Infection In Vivo
309
Probiotics and Emerging Applications 2004
311
EBV Entry and Epithelial Infection
359
EBV Lytic Infection
571
Biological Role of BARF1 Gene Encoded by EpsteinBarr Virus
613
Posttranscriptional Gene Regulation by EBV SM Protein
631
Developing Vaccines Against EBVAssociated Diseases
651
Epstein Barr Virus Cell Based Immunotherapeutics
669
Animal Models
682
EpsteinBarr Virus Related Lymphocryptoviruses of Old and New World
691
EpsteinBarr Virus Summary Conclusions and a Forward Look
711
Index
755
Colour Plates
773
Copyright

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