Pathogenomics: Genome Analysis of Pathogenic Microbes

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Jörg Hacker, Ulrich Dobrindt
John Wiley & Sons, Dec 13, 2006 - Science - 616 pages
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Infectious diseases, caused by many bacteria, are still a serious threat to man and animals, even in developed countries. Besides their virulence, many pathogens gain multiple resistance to drugs that makes them almost -- or even completely -- untreatable using common antibiotics.
This first book to cover the highly dynamic and expanding topic adopts a comprehensive, interdisciplinary approach to focus on those pathogenic bacteria that are of high scientific and public health interest, yet which also display great potential for the development of new diagnostic, prophylactic and therapeutic procedures.
The authors cover all aspects of pathogenomics, clearly divided into sections on methods, genomics and applications. In addition, the ongoing development of genome, transcriptome, proteome and bioinformatic analyses of pathogenic microorganisms and their host interactions makes for a comprehensive introduction to the field of modern genomic analysis.
This result is invaluable to researchers and students wishing to gain a general overview of microbial functional genome analysis and pathogenesis, while also representing a good starting point for those new to the area.
 

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Contents

II Genomics of Pathogenic Bacteria
83
III Genomics of Pathogens and Their Hosts Applications
367
Index
555
Copyright

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About the author (2006)

Jörg Hacker studied biology and performed his doctoral thesis at the Martin-Luther-University of Halle in 1979. He was appointed as Associate Professor in the year 1988 and as Full Professor and Chair for Molecular Biology of Infectious Diseases at the University of Würzburg in 1993. His research interests center on the analysis of pathogenic bacteria and their host organisms, and his laboratory described the first pathogenicity islands as early as the start of the nineties. Jörg Hacker is a member of numerous academies and scientific societies and holds positions on several research bodies. He has received many awards, and was made Honorary Doctor by the University of Umea, Sweden, in 2002 and by the University of Pecs, Hungary, in 2004.

Ulrich Dobrindt graduated with a degree in biology from the University of Göttingen (1995) and a PhD in microbiology (1999) from the University of Würzburg. He received a PhD scholarship from the Boehringer Ingelheim Fonds, and went on to carry out research on gene regulation in uropathogenic E. coli before becoming group leader of the Pathogenic Enterobacteria group at the Institute for Molecular Biology of Infectious Diseases working on enterobacterial genome plasticity focusing on extraintestinal pathogenic E. coli.


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