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activity acute airway allergic alveolar apnoea arterial assessed asthma baseline biopsy blood breathing bronchial bronchitis bronchoalveolar lavage bronchoconstriction bronchodilator bronchoscopy budesonide cells changes chest chronic clinical compared concentration conclude COPD COPD patients correlation corticosteroids cough decrease Department Dept diagnosis dose drug effect eosinophils epithelial evaluated exposure fenoterol FEVj fibrosis flow fluid formoterol histamine Hospital hyperresponsiveness increased induced infection inhaled inhibition investigated Italy levels lung cancer lung disease lung function lymphocytes macrophages males mean age measured Medical Medicine methacholine mmHg months muscle nasal nedocromil neutrophils normal obstruction oxygen Pao2 parameters PEFR performed placebo pleural Pneumology pneumonia predicted pressure protein pulmonary function Pulmonology respiratory response salbutamol salmeterol samples sarcoidosis serum showed significant significantly smoking spirometry sputum steroids subjects symptoms terbutaline theophylline therapy tion tissue tracheal treatment tuberculosis tumour University values ventilation vitro