Concepts in Biochemical Pharmacology: Part 1H.S. Ackermann, Bernard B. Brodie, James R. Gillette This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche mical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. BYRON CLARKE, Director of the Pharmacology-Toxicology Program at the National Insti tutes of Health, whose support made possible much of the work described in this volume. Contents Section One: Routes of Drug Administration Chapter 1: Biological Membranes and Their Passage by Drugs. C. A. M. HOGBEN 1 References. . . . . . . . . . . . . . . . . . . . . . . . . . 8 Chapter 2: Absorption of Drugs from the Gastrointestinal Tract. L. S. SCHANKER. With 5 Figures. 9 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . 9 II. Methods of Study. . . . . . . . . . . . . . . . . . . . . 9 III. Absorption from the Stomach . . . . . . . . . . . . . . . 11 IV. Intestinal Absorption of Non-Electrolytes and Weak Electrolytes 15 V. Absorption of Weak Electrolytes from the Colon and Rectum 18 VI. Intestinal Absorption of Organic Ions. . . . . . . . . . 19 VII. Intestinal Absorption of Macromolecules . . . . . . . . . . 19 VIII. Active Transport across the Intestinal Epithelium . . . . . 20 IX. Effect of EDTA on Drug Absorption from the Intestine . . . . . . . |
Contents
Routes of Drug Administration | 1 |
H Conclusion | 8 |
Absorption of Drugs from the Gastrointestinal Tract L S SCHANKER With 5 Figures | 9 |
Copyright | |
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Other editions - View all
Concepts in Biochemical Pharmacology: Part 1 H.S. Ackermann,Bernard B. Brodie,James R. Gillette Limited preview - 2013 |
Concepts in Biochemical Pharmacology, Part 1 Bernard B. Brodie,James R. Gillette No preview available - 2011 |
Concepts in Biochemical Pharmacology, Part 1 Bernard B. Brodie,James R. Gillette No preview available - 2011 |
Common terms and phrases
absorbed absorption of drugs acid active transport adipose tissue aerosol agents alveolar tension Amer anesthesia anesthetic autoradiography barrier bile biliary excretion binding Biochem blood flow bone brain Brit buccal absorption buffer capillary chemical CHIGNELL clearance clin compounds concentration constant cyclopropane Derm dialysis diffusion distribution DMSO dose effect epidermis epithelium equation fluid fluorescence gastric glands Guinea pig halothane human serum albumin human skin hyaluronidase increase injection interactions intestinal inulin ionized keratin kinetics layer lipid lipid solubility lung mannitol measured mechanism membrane metabolism method molecular weight molecules muscle nitrous oxide particles partition coefficient penetration penicillin percutaneous absorption perfusion permeability pharm Pharmacol phenylbutazone Physiol plasma proteins protein protein-binding Rabbit ratio renal respiratory salicylate SCHANKER serum albumin Skin Cell solution solvent steroids stratum corneum structure studies subcutaneous substances sulphonamides surface Table technique tetracycline Ther thiopental tion uptake Urine vehicle vitro vivo volume