The Endothelium: an introduction to current research
Summarizes the rapid progress of the past ten years in endothelial research and provides an up-to-the-moment account of the most recent and revolutionary developments in this emerging field. Covers the latest discoveries concerning the endothelium's role in nitric oxide production and subsequent effects on blood pressure, blood flow and organ perfusion, in addition to exploring its influence on blood coagulation and inflammation. Various topics within the areas of physiology, pharmacology, atheroma and coagulation, interactions with the immune system and aspects of cell culture are discussed.
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Erik E Anggard The William Har
J F Martin Wellcome Research S Pirotton Institute of Interdisci
Atheroma and Coagulation
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Acad Sci USA agonist angioplasty angiotensin antibodies antigen aortic endothelial cells assay atherosclerosis binding Biochem Biol blood vessels bradykinin Ca2+ calcium Circ Res circulating Clin Invest coagulation converting enzyme coronary arteries cultured HEC cytokines disease EDRF effect endo endothe endothelial cells endothelium endothelium-derived extracellular function growth factor high endothelial histamine human endothelial cells Hypertension Immunol increased induced inflammatory inhibition inhibitor injury interaction interleukin isolated lesions leukocyte lymph node lymphocyte adhesion lymphocytes Maseri mechanisms mediated microvascular migration molecules monocytes myocardial Natl Acad Sci Nature Lond neutrophil nitric oxide patients peptide PGI2 Pharmacol Physiol plasma plasminogen activator platelet Proc Natl Acad production proliferation prostacyclin protein pulmonary rabbit receptors release renal renin response role serum smooth muscle cells stimulation studies surface synthesis t-PA thrombin thrombomodulin tion tissue tissue plasminogen activator vascular endothelial cells vascular smooth muscle vasculitis vasoactive vasoconstriction vessel wall vitro vivo vWFAg