Lectins and Glycoconjugates in OncologyHans-Joachim Gabius, Gerhard Arno Nagel Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis. |
Contents
Introduction | 1 |
Personal History and Priority Hysterics | 49 |
Role of the Target Antigen | 67 |
Copyright | |
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activity antigen Barondes binding sites Biochem biological Biophys biotinylated biotinylated probes BSA BSA BSA BSA-biotin butanol butanol extraction Cancer Res carbohydrate carbohydrate-binding proteins cell line cellular chain conjugates Cramer F cytotoxic deglycosylated ricin A-chain desulf.fucoidan detected differentiation discoidin drug endogenous lectins endothelial cells epithelium expression fibroblasts fucoidan fucose Gabius HJ galactose gangliosides glycoconjugates glycolipids glycoproteins glycosylated GQlb growth factor heparin heparin-binding histochemical human Immunol immunotoxin incubated inflammatory inhibition interactions invasive IT-A Kieda liver lymphocytes MAbs macrophages malignant mannose mediated membrane lectins meningioma metastasis metastatic mice molecular monoclonal antibodies Monsigny mouse mucin murine Natl Acad Sci ng/kg non-transformed normal oligosaccharide p-CAM plasma membrane polysaccharides Proc Natl Acad proteins receptors recognition ricin ricin A-chain immunotoxin Roche AC role Schauer serum sialic acid sialidase small cell anaplastic specific staining structures sugar sulfated polysaccharides surface carbohydrates surface molecules target tissue transformed tumor tumor cells Uhlenbruck uptake vitro vivo