Bioanalysis and Biosensors for Bioprocess Monitoring, Volume 66
Springer, 2000 - Science - 244 pages
The contributions to this special volume were selected in order to show present trends in the field of bioprocess monitoring and estimation. Established conventional methods are critically discussed and non-conventional ones introduced. Two papers focus on more fuzzy approaches such as electronic noses or advanced chemometric techniques. One contribution illustrates the high potential with the example of cephalosporin production. Three contributions dare to "look" inside the cells, one by the analysis of (microscopic) images, one by trying to estimate the so-called physiological state, and the third by analyzing the metabolic network. This shows how sophisticated (bio)chemical as well as mathematical analytical tools result in better understanding of living systems and bioprocesses.
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Instrumentation of Biotechnological Processes
B Sonnleitner 1
Real Time Considerations
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acid Anal Chim Acta analytical Appl Environ Microbiol Appl Microbiol Biotechnol applied automated bacteria Biochem biological biomass biomass concentration bioprocess bioreactor biosensor Biotechnol Bioeng Biotechnology carbon cells cellular cephalosporin Chem chemical Chemometrics chrysogenum coli components cultivation culture descriptors detection detector determined electronic nose enzyme Enzyme Microb Technol estimation ethanol Fiechter filamentous filter flow cytometry fluorescence fluxes glucose Goodacre gray-level growth Heinzle image analysis infrared intracellular isotope balancing isotopomers labeling patterns Mass Spectrometry measured medium membrane metabolic channeling metabolic network metabolite metabolite balancing microbial microorganisms microscope molecules morphology MOSFET Nielsen off-line on-line optical oxaloacetate oxide oxygen parameters pathways pellet pentose phosphate pathway phase pixels prediction production protein Pyrolysis pyruvate quantitative Raman Raman spectroscopy reactions reactor Saccharomyces cerevisiae sample Schematic design Scheper Schugerl sensors signal Sonnleitner spectra spectroscopy staining Stockar substrate technique tion variables yeast