Methotrexate

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Bruce N. Cronstein, Joseph R. Bertino
Springer Science & Business Media, 2000 - Medical - 139 pages
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This book provides multidisciplinary reviews of the mechanism of action and uses of methotrexate in the treatment of cancer, psoriasis, gynecologic and inflammatory diseases. The intended audience is composed of clinicians involved in the care of patients suffering from oncologic, gynecologic, rheumatic diseases as well as scientists involved in research into the pathogenesis and treatment of these diseases. This book is unique in that it provides a single, state-of-the-art source for information regarding the mechanism and use of methotrexate in many different areas of medicine.
 

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Contents

historical aspects
1
Methotrexate its mechanism of action in malignant disease and mechanisms of resistance by malignant cells
9
Current use of methotrexate in the treatment of malignancies in adults
31
The use of methotrexate in the treatment of childhood malignancies
49
The mechanisms of methotrexates action in the treatment of inflammatory disease
65
Methotrexate in rheumatoid arthritis
83
Use of methotrexate in the treatment of psoriasis and other dermatological disorders
109
The use of methotrexate in gynecological practice
125
Index
137
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