Systemic MMP Inhibition Augments Wound Repair in Advanced Periodontitis: A Controlled Clinical Trial : this Thesis was Submitted in Fulfillment ... for the Degree of Master of Science in Periodontics ... |
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12 months activity addition administration adult periodontitis adverse events analyses antibiotic assessed attachment level baseline bleeding bone capsules Caton cells changes Characteristics clinical parameters collagen collagenase compared compliance consent criteria degradation demonstrated destruction determined differences Dose Doxycycline LDD drug effects efficacy enzymes evaluated examination expression Figure Gelatinase Giannobile gingival given Golub Golub et al host human ICTP levels increase indicated inhibit inhibitor initial Low Dose Doxycycline matrix metalloproteinases mean measurements medication Michigan microbial molecule Myocardial Infarction noted participate patients percentage performed period periodontal disease placebo group plaque pocket depth predicting probing depth procedure Protease received recorded reduction regimen reported response samples scaling showed shown significant differences specific standard statistically significant study medication subgingival surgery Table tetracycline therapy tissue treatment trial utilizing