NMR in Biological Systems: From Molecules to Human

K.V.R. Chary, Girjesh Govil

Springer Science & Business Media, Apr 8, 2008 - Science - 524 pages

During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials. This book builds a means of knowledge transfer between the beginners and the experts in NMR as applied to all aspects of life sciences.

Contents

• BASIC CONCEPTS IN NMR SPECTROSCOPY: 1
• PROTEIN DYNAMICS 4 1 NMR Parameters for Studying Dynamics: 4
• THREE DIMENSIONAL 3D EXPERIMENTS: 7
• NMR SPINS USED IN LIFE SCIENCES: 11
• NMR RELAXATION: 23
• REFERENCES: 40
• LEVELS OF BIOLOGICAL STRUCTURES: 47
• 2: 61
• 23: 74
• 24: 85
• TECHNIQUES FOR SOLUTION NMR OF VERY LARGE: 108
• ELEMENTS OF MACROMOLECULAR STRUCTURES: 119
• NMR PARAMETERS FOR STRUCTURAL STUDIES: 133
• DATA BANKS FOR STRUCTURES AND NMR OF BIOMOLECULES: 160
• AUTOMATED NMR ASSIGNMENTS IN PROTEINS: 197
• PROTONLESS MULTIDIMENSIONAL: 203
• STRUCTURE DYNAMICS AND FUNCTION: 211
• PROTEIN FOLDING AND UNSTRUCTURED PROTEINS: 219
• PARAMAGNETIC PROTEINS: 232
• FUNCTIONAL ASPECTS STUDIED: 240
• STRUCTURE AND DYNAMICS OF NUCLEIC ACIDS: 247
• NMR SPECTROSCOPY OF NUCLEIC ACIDS: 256
• NMR PARAMETERS IN NUCLEIC ACIDS: 264
• UNUSUAL DNA STRUCTURES: 273
• Vaccines: 301
• NMR STUDIES OF STRUCTURE AND DYNAMICS: 308
• IN NMR SPECTROSCOPY: 314
• HIGHRESOLUTION SOLIDSTATE: 317
• PROTEIN STRUCTURE DETERMINATION USING: 338
• 6: 348
• BIOMOLECULAR INTERACTIONS: 351
• 4: 372
• MAGNETIC RESONANCE IMAGING: 377
• MRI AS A CLINICAL TOOL 8 1 Central Nervous System: 415
• STUDY OF METABOLISM CELLS AND TISSUES: 423
• STUDIES OF TISSUES USING SOLIDSTATE NMR TECHNIQUES: 449
• 1: 467
• 7: 485
• PLANT METABOLISM USING: 496
• 8: 507
• 3D TRIPLERESONANCE EXPERIMENTS FOR PROTEINS: 515

Bibliographic information

• Title: NMR in Biological Systems: From Molecules to Human; Volume 6 of Focus on Structural Biology
• Authors: K.V.R. Chary, Girjesh Govil
• Edition: illustrated
• Publisher: Springer Science & Business Media, 2008
• ISBN: 1402066791, 9781402066795
• Length: 524 pages
• Subjects: Medical / Allied Health Services / Imaging Technologies; Medical / Biochemistry; Science / Biotechnology; Science / Chemistry / Physical & Theoretical; Science / Life Sciences / Biochemistry; Science / Life Sciences / Biophysics; Science / Life Sciences / General