Polyunsaturated fatty acids in human nutrition

Front Cover
Raven Press, 1992 - Medical - 243 pages
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This volume highlights the important clinical implications of recent findings on the biochemistry, metabolism, and physiological functions of long chain polyunsaturated fatty acids (LCPUFAs). Leading experts define the relationships between dietary LCPUFAs and their structural-metabolic physiological role, examine the influence of LCPUFAs and other essential fatty acids on infant development, discuss the evidence linking various disorders to essential fatty acid imbalance, and describe new approaches to problems relating to dietary LCPUFAs, particularly in infant feeding.
The contributors review the most significant research on the transport and cellular utilization of LCPUFAs, their role in phospholipid molecular species, their extracellular and intracellular fates, their metabolism to oxidative derivatives, and their functions as mediators - through eicosanoid-dependent and/or independent mechanisms - brain and retinal development, immunomodulation, and other physiological processes. Extensive studies explore the relationship between essential fatty acid balance and cystic fibrosis, behavior problems, chronic diseases, atopic dermatitis, gynecological and reproductive disorders, and disturbances of lipoprotein metabolism. Full consideration is given to the intake, digestion, absorption, and metabolism of LCPUFAs in newborn infants and the special problems of premature infants and infants with peroxisomal disorders. Practical issues concerning sources and uses of dietary LCPUFAs are also discussed in detail.
Polyunsaturated Fatty Acids in Human Nutrition is an essential source of information for nutritionists, pediatricians, and clinicians treating disorders involving fatty acid imbalance. The book will also be a valuable stimulus for basic researchers investigating the role of fatty acids in human biology.

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Past and Future
Long Chain Fatty Acid Metabolism
Physical Properties of Fatty Acids and their Extracellular

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