Pharmacology is now firmly established as a world wide best-selling and highly acclaimed textbook for medical and science students. Its successful approach emphasies the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses. It sets out for the reader a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs. For the Fifth Edition the text has been completely updated, incorporating significant new information published in the last few years, while obsolete material has been removed. New agents are fully discussed as well as extensions of basic knowledge which presage further drug development. Book jacket.
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Measurement in Pharmacology
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acetylcholine action potential activity adrenoceptor agents agonists amino acids amphetamine anesthetics antagonists antidepressant anxiolytic asthma benzodiazepines binding block blood bradykinin brain calcium cancer cardiac cause cells channels chemical cholinergic clinical compounds decrease depolarization depression disease diuretics dopamine dose drugs enzyme epinephrine estrogen ethanol excreted factor function GABA gastrointestinal glucocorticoids histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous involved lipid liver mainly mechanism of action mediators membrane metabolism metabolites molecules morphine muscarinic nerve terminals nervous system neuroleptic neurons nicotine noradrenergic norepinephrine normal NSAIDs occurs opioid oxide pathway patients peptide peripheral Pharmacokinetic pharmacological physiological pituitary plasma plasma concentration platelets produce prostaglandins protein reactions receptors reduced release renal response result secretion side effects smooth muscle sodium steroids stimulation substances synaptic synthesis therapeutic therapy tion tissues toxicity transmission transmitter treatment Trends Pharmacol Sci tubule types Unwanted effects uptake urine vascular vitamin