Strategy of Drug Design: A Guide to Biological Activity |
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00 STANDARD ERROR acid activity contributions Amer AMOUNT OF EXPLAINED analog atoms Biochem biological activity Biophys Br]x calculated Cammarata CARIES PILOT PROJECT Chapter Chem chemical COEFFICIENT SIGNIFICANCE congeners constant drug design E. J. Lien ERROR OF PARTIAL example experimental EXPLAINED VARIANCE FORMAT Fujita GROWTH INHIBITION STUDIES Hammett Hammett equation Hansch HYDROFLUORIDES VS STREP hydrophobic INDEPENDENT VARIABLES FOLLOW INHIBITION STUDIES VARIABLES interaction Kakeya LFER model Linear Free log 1/C logarithm matrix method molar molecular orbital molecules MULTIPLE CORRELATION MULTIPLE CORRELATION COEFFICIENT NO₂ly number of observations obtained octanol PARTIAL REGRESSION COEFFICIENTS partition coefficient Pharm Pharmacol physicochemical parameters potency predicted QSAR quantitative quantum mechanical regression analysis REGRESSION F SB(J selected series of compounds SIGNFICANCE OF REGRESSION solution Steric Effects steric parameter structure-activity substituent groups substituent positions synthesis Taft tion TURBIDIMETRIC GROWTH INHIBITION VALUES FOR COEFFICIENT VARIABLES FOLLOW 1.000 W. P. Purcell WRITE ΡΙ