Bile Acids and Hepatobiliary Diseases - Basic Research and Clinical ApplicationG. Paumgartner, A. Stiehl, W. Gerok Since the last International Bile Acid Meeting in San Diego in 1994, new advances have been made in the understanding of bile acid metabolism and transport. The cytotoxic as well as the therapeutic effects of specific bile acids have been further explored and the beneficial effects of ursodeoxycholic acid in various chronic cholestatic conditions have been substantiated. Much basic and clinical research has been conducted to unravel the underlying mechanisms of action. This volume, the proceedings of Falk Symposium No. 93 (XIV International Bile Acid Meeting), held in Freiburg-im-Breisgau, Germany, October 22-24, 1996, is dedicated to both basic and clinical aspects of bile acid research related to the role of bile acids in hepatobiliary diseases. |
Contents
Identification of a unique inborn error in bile acid conjugation | 43 |
a key cytochrome P450 in bile | 63 |
Stereochemistry of peroxisomal sidechain degradation | 73 |
Copyright | |
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Common terms and phrases
absorption activity addition bile acid transport bile salts biliary biliary bile acid binding Biochem Biol Chem canalicular canalicular membrane cathepsin cells changes characterization cholestasis cholesterol cholic acid Clin cloning compared composition concentrations conjugates decreased demonstrated deoxycholic determined effect enzyme et al evidence excretion experiments expression fraction function Gastroenterology gene hepatic hepatocytes Hepatology human identified ileal important increased indicate induced inhibition inhibitors intestinal involved isolated kinase Kramer levels lipid liver disease mdr2 measured mechanism mediated membrane mmol/L molecular mRNA mutations Na+/bile acid normal Ntcp observed obtained occur organic anions P-glycoprotein pathway patients phospholipid photoaffinity labelling Physiol plasma present primary biliary cirrhosis protein rabbit rat hepatocytes rat liver recently regulation role secretion sequence serum showed shown signal significant similar specific stimulation structure studies substrate suggest synthesis taurocholate transport system treatment UDCA uptake ursodeoxycholic acid