Chemistry and Biology of Hyaluronan

Front Cover
Hari G. Garg, Charles A. Hales
Elsevier, Jul 14, 2004 - Science - 624 pages
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It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow.

Expertly written by leading scientists in the field, this book provides readers with a broad, yet detailed review of the chemistry of hyaluronan, and the role it plays in human biology and pathology. Twenty-seven chapters present a sequence leading from the chemistry and biochemistry of hyaluronan, followed by its role in various pathological conditions, to modified hylauronans as potential therapeutic agents and finally to the functional, structural and biological properties of hyaluronidases. Chemistry and Biology of Hyaluronan covers the many interesting facets of this fascinating molecule, and all chapters are intended to reach the wider research community.

  • Comprehensive look at the chemistry and biology of hyaluronans
  • Essential to Chemists, Biochemists and Medical researchers
  • Broad yet detailed review of this rapidly growing research area
 

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Contents

Chapter 1 Solution Properties of Hyaluronan
1
Chapter 2 Methods for Analysis of Hyaluronan and Its Fragments
21
Chapter 3 Methods for Determination of Hyaluronan Molecular Weight
41
Chapter 4 Biodegradation of Hyaluronan
71
CD44
83
Chapter 6 The Role of the Hyaluronan Receptor RHAMM in Wound Repair and Tumorigenesis
125
Chapter 7 Signal Transduction Associated with Hyaluronan
153
Chapter 8 Structural and Functional Diversity of HyaluronanBinding Proteins
189
Chapter 16 Hyaluronan Biology in Vocal Fold Morphology and Biomechanics
339
Chapter 17 Hyaluronan in Aging
351
Chapter 18 Hyaluronan and Scarring
367
Chapter 19 Hyaluronan in the Epidermis and Other Epithelial Tissues
395
Chapter 20 Viscoelastic Properties of Hyaluronan and Its Therapeutic Use
415
Chapter 21 Medical Applications of Hyaluronan
457
Chapter 22 Therapeutic Biomaterials from Chemically Modified Hyaluronan
475
Chapter 23 Medicinal Uses of Modified Hyaluronate
505

Chapter 9 Biological Function of SHAPHyaluronan Covalent Complex
205
Chapter 10 Hyaluronan and Associated Proteins in the Visual System
223
Chapter 11 Hyaluronan in the Pulmonary Alveolus and Interstitium
247
Chapter 12 Hyaluronan in VentilatorInduced Lung Injury
271
Chapter 13 The Role of Hyaluronan in Cancer
285
Chapter 14 Hyaluronan in Atherosclerosis and Restenosis
307
Chapter 15 Hyaluronan in the Airways
323
Chapter 24 Hyaluronan in the Treatment of Ocular Surface Disorders
529
Chapter 25 The Hyaluronan Synthases
553
Chapter 26 Molecular Genetic Dissection of Hyaluronan Function in the Mouse
569
Chapter 27 Functional Structural and Biological Properties of Hyaluronidases
585
Index
599
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