Anandamide

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Academic Press, Jul 29, 2009 - Science - 536 pages
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume reviews recent advances in the formation of endogenous cannabinoids and their receptors, metabolism and relation to disease processes.

*Longest running series published by Academic Press *Contributions by leading international authorities

 

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Contents

Enzymatic Formation of Anandamide
1
Organized Trafficking of Anandamide and Related Lipids
25
Biosynthesis of Oleamide
55
Anandamide Receptor Signal Transduction
79
Is GPR55 an Anandamide Receptor?
111
The Endocannabinoid System During Development Emphasis on Perinatal Events and Delayed Effects
139
Cannabinoid Receptor CB1 Antagonists State of the Art and Challenges
159
Novel Endogenous NAcyl Glycines Identification and Characterization
191
Modulation of the CysLoop LigandGated Ion Channels by Fatty Acid and Cannabinoids
315
Endogenous Cannabinoids and Neutrophil Chemotaxis
337
CB1 Activity in Male Reproduction Mammalian and Nonmammalian Animal Models
367
Anandamide and the Vanilloid Receptor TRPV1
389
Endocannabinoid System and Fear Conditioning
421
Regulation of Gene Transcription and Keratinocyte Differentiation by Anandamide
441
Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
469
Use of Cannabinoids as a Novel Therapeutic Modality Against Autoimmune Hepatitis
487

The Endocannabinoid Anandamide From Immunomodulation to Neuroprotection Implications for Multiple Sclerosis
207
Modulation of the EndocannabinoidDegrading Enzyme Fatty Acid Amide Hydrolase by FollicleStimulating
231
GlucocorticoidRegulated Crosstalk Between Arachidonic Acid and Endocannabinoid Biochemical Pathways Coordin
263

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About the author (2009)

Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

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