Anandamide

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Academic Press, Jul 29, 2009 - Science - 536 pages
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume reviews recent advances in the formation of endogenous cannabinoids and their receptors, metabolism and relation to disease processes.



*Longest running series published by Academic Press *Contributions by leading international authorities

 

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Contents

Enzymatic Formation of Anandamide
1
Organized Trafficking of Anandamide and Related Lipids
25
Biosynthesis of Oleamide
55
Anandamide Receptor Signal Transduction
79
Is GPR55 an Anandamide Receptor?
111
The Endocannabinoid System During Development Emphasis on Perinatal Events and Delayed Effects
139
Cannabinoid Receptor CB1 Antagonists State of the Art and Challenges
159
Novel Endogenous NAcyl Glycines Identification and Characterization
191
Modulation of the CysLoop LigandGated Ion Channels by Fatty Acid and Cannabinoids
315
Endogenous Cannabinoids and Neutrophil Chemotaxis
337
CB1 Activity in Male Reproduction Mammalian and Nonmammalian Animal Models
367
Anandamide and the Vanilloid Receptor TRPV1
389
Endocannabinoid System and Fear Conditioning
421
Regulation of Gene Transcription and Keratinocyte Differentiation by Anandamide
441
Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
469
Use of Cannabinoids as a Novel Therapeutic Modality Against Autoimmune Hepatitis
487

The Endocannabinoid Anandamide From Immunomodulation to Neuroprotection Implications for Multiple Sclerosis
207
Modulation of the EndocannabinoidDegrading Enzyme Fatty Acid Amide Hydrolase by FollicleStimulating
231
GlucocorticoidRegulated Crosstalk Between Arachidonic Acid and Endocannabinoid Biochemical Pathways Coordin
263

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About the author (2009)

Trained in biochemistry at the University of Wisconsin, Madison, Dr. Litwack worked on enzymology and the effects of hormones on enzyme systems. Then he was a Postdoctoral Fellow of the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. Dr. Litwack's first position was as Assistant Professor of Biochemistry at Rutgers University in 1954. Six years later, he joined the University of Pennsylvania as associate professor and four years later went to the Fels Institute for Cancer Research and Molecular Biology, as full professor, eventually becoming Deputy Director of the Institute. In 1991, he accepted the Chair of Pharmacology at Thomas Jefferson University where he is also Deputy Director of the Jefferson Cancer Institute and Associate Director for Basic Science in the Jefferson Cancer Center. Dr. Litwack's work has been in the area of mechanisms of steroid receptor action involving especially the glucocorticoid and mineralocorticoid receptors, immunophi.

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