Anandamide

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Academic Press, Jul 29, 2009 - Science - 536 pages
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume reviews recent advances in the formation of endogenous cannabinoids and their receptors, metabolism and relation to disease processes.



*Longest running series published by Academic Press *Contributions by leading international authorities

 

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Contents

Enzymatic Formation of Anandamide
1
Organized Trafficking of Anandamide and Related Lipids
25
Biosynthesis of Oleamide
55
Anandamide Receptor Signal Transduction
79
Is GPR55 an Anandamide Receptor?
111
The Endocannabinoid System During Development Emphasis on Perinatal Events and Delayed Effects
139
Cannabinoid Receptor CB1 Antagonists State of the Art and Challenges
159
Novel Endogenous NAcyl Glycines Identification and Characterization
191
Modulation of the CysLoop LigandGated Ion Channels by Fatty Acid and Cannabinoids
315
Endogenous Cannabinoids and Neutrophil Chemotaxis
337
CB1 Activity in Male Reproduction Mammalian and Nonmammalian Animal Models
367
Anandamide and the Vanilloid Receptor TRPV1
389
Endocannabinoid System and Fear Conditioning
421
Regulation of Gene Transcription and Keratinocyte Differentiation by Anandamide
441
Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer
469
Use of Cannabinoids as a Novel Therapeutic Modality Against Autoimmune Hepatitis
487

The Endocannabinoid Anandamide From Immunomodulation to Neuroprotection Implications for Multiple Sclerosis
207
Modulation of the EndocannabinoidDegrading Enzyme Fatty Acid Amide Hydrolase by FollicleStimulating
231
GlucocorticoidRegulated Crosstalk Between Arachidonic Acid and Endocannabinoid Biochemical Pathways Coordin
263

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About the author (2009)

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, “One-Eighty .

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