Design Principles for the Immune System and Other Distributed Autonomous Systems
Lee A. Segel, Irun R. Cohen
Oxford University Press, Jun 14, 2001 - Mathematics - 428 pages
Design Principles for the Immune System and Other Distributed Autonomous Systems is the first book to examine the inner workings of such a variety of distributed autonomous systems--from insect colonies to high level computer programs to the immune system. It offers insight into the fascinating world of these systems that emerge from the interactions of seemingly autonomous components and brings us up-to-date on the state of research in these areas. Using the immune system and certain aspects of its functions as a primary model, this book examines many of the most interesting and troubling questions posed by complex systems. How do systems choose the right set of agents to perform appropriate actions with appropriate intensities at appropriate times? How in the immune system, ant colonies and metabolic networks does the diffusion and binding of a large variety of chemicals to their receptors permit coordination of system action? What advantages drive the various systems to complexity, and by what mechanisms do the systems cope with the tendency toward unwieldiness and randomness of large complex systems?
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activated adaptive immune adaptive immune system affinity affinity maturation allograft anergy antibodies antigen ants Arthritis autoimmune behavior binding biological CD4+ Chem chemical chemokines clonal clones clonotypes codelets colony complex Copycat costimulation cytokines dendritic cells detection detector different MHC molecules differentiation disease Distributed Autonomous Systems documents effect effector epitopes evolved example experimental expression Factor feedback foragers function genes genetic algorithm Golem H. L. Weiner host Human immune response immune system Immunol immunology individual induce inflammation inflammatory information resources inhibit integrins interactions Interleukin intracellular keywords leukocytes ligands lymphocytes macrophages mechanisms mediated memory MHC diversity mice Monocytes multistep negative selection nest maintenance Oral Administration oral tolerance pathogens patterns peptides Peyer's patches principle production proliferation proteins reaction receptor-ligand pairs receptors Regulation repertoire role secretion Segel semantic signal social insects specific stimulated structure Suppression T-cell TalkMine task Th cells threshold tion tissue TNF-a triggered users
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