Mass Spectrometry: A TextbookWhen non-mass spectrometrists are talking about mass spectrometry it rather often sounds as if they were telling a story out of Poe's Tales of Mystery and Imagi- tion. Indeed, mass spectrometry appears to be regarded as a mysterious method, just good enough to supply some molecular weight information. Unfortunately, this rumor about the dark side of analytical methods reaches students much earlier than their first contact with mass spectrometry. Possibly, some of this may have been bred by mass spectrometrists themselves who tended to celebrate each mass spectrum they obtained from the gigantic machines of the early days. Of course, there were also those who enthusiastically started in the 1950s to develop mass spectrometry out of the domain of physics to become a new analytical tool for chemistry. Nonetheless, some oddities remain and the method which is to be introduced herein is not always straightforward and easy. If you had asked me, the author, just after having finished my introductory course whether mass spectrometry would become my preferred area of work, I surely would have strongly denied. On the other hand, J. J. Veith's mass spectrometry laboratory at Darmstadt Univ- sity was bright and clean, had no noxious odors, and thus presented a nice contrast to a preparative organic chemistry laboratory. Numerous stainless steel flanges and electronics cabinets were tempting to be explored and – whoops – infected me with CMSD (chronic mass spectrometry disease). |
Contents
| 1 | |
| 13 | |
Isotopes | 67 |
Instrumentation | 111 |
Electron Ionization | 193 |
Fragmentation of Organic Ions and Interpretation of EI Mass Spectra | 223 |
Chemical Ionization | 331 |
Field Ionization and Field Desorption | 355 |
Electrospray Ionization | 441 |
Hyphenated Methods | 475 |
Appendix | 495 |
Carbon Isotopic Patterns | 501 |
Silicon and Sulfur Isotopic Patterns | 502 |
Chlorine and Bromine Isotopic Patterns | 503 |
Frequent Impurities | 505 |
| 506 | |
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Common terms and phrases
a-cleavage abundance accurate mass acid Adapted from Ref aliphatic alkene Anal Analysis analyte atoms bond carbenium ion carbon cation Chap Chem chemical ionization cleavage cluster ions collision compounds detection detector dissociation electron ionization electrospray emitter Example Field Desorption fragment ions FT-ICR gas phase hydrogen internal energy ion formation Ion Phys Ion Proc ion source ionic ionization methods isomerization isotope effects isotopic pattern John Wiley kinetic energy laser linear liquid lons loss m/z Fig m/z values MALDI MALDI-MS mass analyzer Mass Spec Mass Spectrom Mass Spectrometry matrix McLafferty rearrangement metastable molecular ion molecule neutral NIST nominal mass peak at m/z Peptides permission of NIST precursor ion Proteins proton quadrupole ion trap radical radical ion Rapid Commun ratio reaction reagent gas relative intensity Reproduced from Ref resolution sample scan sector instruments signal spectra Tandem thermal time-of-flight tion trometry vacuum voltage Wiley & Sons yield