Principles of Molecular Medicine

Front Cover
Marschall S. Runge, Cam Patterson
Springer Science & Business Media, Nov 18, 2007 - Medical - 1268 pages
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The concept of molecular medicine dates back to Linus means that there are many new opportunities and challenges Pauling, who in the late 1940s and early 1950s generalized for clinical medicine. One of the effects of the completion of from the ideas that came from the study of the sickle cell the Human Genome Project is the increasing application of hemoglobin molecule. With the first cloning of human genes the fields of molecular biology and genetics to the und- about 1976, molecular genetics took the molecular perspec- standing and management of common diseases. Assimi- tive on disease to the level of DNA. The term molecular tion of the new developments since the first edition has been medicine achieved wide currency in the 1980s with the ably accomplished by Drs. Runge and Patterson with the assignment of this designation to journals, at least one soci- help of their many knowledgeable authors. ety, institutes, and academic divisions of departments of in- As was evident in the first edition, molecular genetics is ternal medicine. Undoubtedly, molecular medicine has been involved in every specialty of medicine. A recurrent theme abetted by the Human Genome Project, which has aided in that edition, perhaps even more striking in the present one, greatly in the molecular characterization of disease.
 

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Contents

99
560
101
566
of Helicobacter pyloriAssociated
590
NEPHROLOGY
604
MUSCULOSKELETAL
664
Mechanisms
693
Rhabdomyosarcomas
700
72
709

VII
45
Genetic Counseling
46
Animal Models in Biomedical
53
CARDIOLOGY
67
9
73
27
87
39
96
Emerging Concepts
105
Artery Disease
130
Hypertension
138
Cardiac Hypertrophy
146
Arrhythmias
157
Genomics
166
Cardiovascular Gene Therapy
175
III
186
Asthma
198
29
269
Disorders of Pulmonary Surfactant
277
ENDOCRINOLOGY
287
Thyroid Disorders
337
Adrenal Diseases
377
XII
490
96
510
METABOLIC DISORDERS
512
of Sarcopenia
529
Adipose Tissue Development
535
GASTROENTEROLOGY
541
97
551
Molecular Diagnostics in Hepatitis B
554
74
720
Breast Cancer
728
Lung Cancer
736
79
767
A Story of Genes
804
HEMATOLOGY
829
HIV Molecular Biology Treatment
905
k Cellular and Molecular Aspects
912
95
919
DERMATOLOGY
935
James T Elder
948
Pemphigus Foliaceus Pemphigus Vulgaris
959
Systemic Lupus Erythematosus
970
Systemic Sclerosis
979
Diseases With Signaling and Transcriptional
991
Genetic Skin Diseases With Neoplasia
998
109
1034
NEUROLOGY
1071
CharcotMarieTooth Disease and Related
1097
Parkinsons Disease
1123
Prion Diseases
1142
Sleep Disorders
1153
Axonal Regeneration and Recovery
1165
PSYCHIATRY
1174
128
1183
Antidepressant
1191
Anxiety Disorders
1197
INDEX
1237
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