Cell and Molecular Biology of the Cytoskeleton
Springer US, May 31, 1986 - Science - 356 pages
Cell and Molecular Biology of the Cytoskeleton focuses on the three major fibrous proteins in the cytoplasm that are collectively known as the cytoskeletal sys tem. These polymorphic cytoskeletal proteins are microtubules (25-nm diam eter), microfilaments (6-nm diameter), and intermediate filaments (l O-nm diameter). Microtubules consist of tubulin and several well-characterized mi crotubule-associated proteins (MAPs) such as MAPl, MAP2, and tau. Micro filaments consist of actin and associate with actin-binding proteins, including alpha-actinin, filamin, myosin, tropomyosin, vinculin, and others. Intermedi ate filaments consist of at least five different tissue-specific classes, including desmin or skeletin (muscle), prekeratin (epithelial), vimentin (mesenchymal), neurofilament (nerve), and glial acidic fibrillary protein (astrocytes). In this volume distinguished researchers in the field cover the interaction of these fibrous proteins, not only with each other and other cytoplasmic components, but also with such biological processes as cell shape changes, growth, motility, secretion, and division. These comprehensive reviews ex plore the cytoskeleton's molecular, biochemical, and structural properties with an emphasis on their manifestation in the living cell.
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Acad actin gene activity addition amino acid analysis animal antibody assembly associated B-tubulin binding brain brain tubulin cDNA Cell Biol cellular changes chromosome Cleveland cloned coiled-coil colchicine complete concentrations contain cultured cytokeratin cytoplasmic cytoskeletal demonstrated desmin determined differentiation distribution domain dynamics effect encoding epidermal et al evidence experiments expression factor fibroblasts Figure flagellar formation Fuchs function Geisler growth human hybridization increase indicate induced inhibited injected interaction intermediate filaments intron isoforms isolated keratin labeled levels MAPs mechanism membrane microfilament microinjected microtubules molecular mouse mRNA muscle myosin Nature observed organization pattern plant polarity polymerization polypeptides positions possible present probe Proc proteins regions regulation relative reported residues sequences showed shown similar specific spindle Steinert stress fibers structure studies subunits suggest synthesis tion tissue transcription translation tubulin vimentin vitro Weber