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acid activity analysis angiogenesis antibody anticancer antitumor apoptosis apoptotic assay binding Biol bortezomib BP T4 breast cancer cancer cell lines Cancer Res carcinoma cell death cell proliferation cetuximab Chem cisplatin Clin clinical clones colorectal cancer culture cytoplasm cytotoxic detected dose drug effect EGFR endothelial cells enhanced erlotinib expression Figure fluorescence gastric gefitinib gene gossypol growth factor human HUVEC increased incubated induced inhibition inhibitor injected integrin interaction invasion kinase liposomes liver LPP-HMGA2 lung malignant Materials and Methods melanoma membrane metastasis metastatic methylation mice molecular mouse mRNA NF-kB Oncogene Oncol oral patients PC-3 cells peptide phosphorylation prostate cancer protein pylori quercetin receptor ribozyme riluzole role serum shown significant significantly Smad4 staining Stat3 target TGF-P signalling therapeutic therapy tissue TNF-a transcription transfected treated treatment tumor tumor cells tumor growth ubiquitin ug/ml VEGF vitro vivo Western blot