The Macrophage as Therapeutic Target

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Springer Science & Business Media, Jul 10, 2003 - Medical - 496 pages

During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents.

The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters.

 

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Contents

The Macrophage as a Validated Pharmaceutical Target
3
Transcription Factors That Regulate Macrophage Development and Function
11
Exploitation of Macrophage Clearance Functions In Vivo
41
Routes of Delivery
55
AntigenPresenting Cells and Vaccine Design
67
MacrophageSpecific Gene Targeting In Vivo
89
Integrins of Macrophages and MacrophageLike Cells
111
Purinergic Receptors
131
Proteases
253
Targeting the Chemokine System
269
Antimicrobial Peptides
295
Macrophage Phospholipid Products
305
Common and Unique Features
337
The Osteoclast
353
Macrophages in the Central and Peripheral Nervous System
373
by Macrophage and Related Receptors Potential Ligands for Antiviral Agents
385

Macrophage Lipid Uptake and Foam Cell Formation
147
Dietary Fatty Acids and Macrophages
173
Macrophages as Therapeutic Targets in Lysosomal Storage Disorders
193
Nuclear Receptors as Regulators of Macrophage Homeostasis and Function
209
Relationships Between Reactive Oxygen Species and Reactive Nitrogen Oxide Species Produced by Macrophages
227
Macrophage Immunity and Mycobacterium tuberculosis
409
The Role of Carbohydrates and Antifungal Agents
459
Subject Index
479
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