Bile acids in liver diseases: proceedings of the International Falk Workshop held in Munich, Germany, January 26-27, 1995
Bile acid research has attracted increasing attention from both basic scientists and clinical hepatologists over the last decade. Experimental studies have expanded our knowledge of the role of bile acids in liver disease, and well-designed clinical trials have documented beneficial effects of bile acid treatment for a number of hepatobiliary diseases. Bile Acids in Liver Diseases, the proceedings of an International Falk Workshop held in Munich, January 1995, provides insights into current concepts in bile acid chemistry, bile acid synthesis and metabolism, and transport of bile acids across the hepatocyte. The role of bile acids in bile formation, cholestasis and hepatotoxicity are discussed. Finally, the book addresses experimental studies and hypotheses about the putative mechanisms of action of ursodeoxycholic acid in cholestatic liver diseases, and summarizes the clinical applications of bile acid treatment on the basis of controlled clinical trials.
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Ursodeoxycholic acid in cholestatic
Role of alternative pathways of bile acid biosynthesis
Hepatocellular basolateral bile acid uptake proteins
8 other sections not shown
7-dehydroxylation activity apoptosis ATP-dependent basolateral bile acid biosynthesis bile acid synthesis bile acid transport bile alcohols bile duct bile flow bile salt biliary secretion Biochem Biol Chem Boyer JL Ca2+ canalicular canalicular membrane cell chenodeoxycholic acid cholanoids cholate cholestasis cholesterol cholesterol 7a-hydroxylase cholic acid Clin Invest cloning concentrations conjugates cotransport cytosolic decrease endogenous bile acids enterohepatic circulation enzyme excretion Falk Symposium function Gastroenterology gene Hagenbuch Hagey LR HCO3 hepatic hepatocellular hepatocytes Hepatology HMG-CoA reductase inhibitor Hofmann human hydrophobic hydroxylation Hylemon PB increased induced inhibition intestinal intracellular isolated rat hepatocytes Lipid Lipid Res lithocholate liver disease mechanisms Meier PJ metabolism molecular molecules mRNA Na+-dependent necrosis Ntcp oatp organic anions pathway patients Paumgartner G perfused rat liver phospholipid Physiol physiological plasma membrane polarity primary sclerosing cholangitis regulation Schteingart CD side-chain Sjovall steroid Stieger stimulation studies taurine Tauroursodeoxycholic toxic translocation transport proteins TUDCA UDCA uptake ursodeoxycholic acid