The Essence of Analgesia and Analgesics
Raymond S. Sinatra, Jonathan S. Jahr, J. Michael Watkins-Pitchford
Cambridge University Press, Oct 14, 2010 - Medical
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
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acetaminophen acid activity acute pain administration adverse events agents agonists Analg analgesia analgesic analgesic effects Anesth anesthesia Anesthesiology anesthetic antagonist aprepitant aspirin associated bupivacaine buprenorphine cancer pain catheter channels Chemical Structure chronic pain Clin clinical clonidine codeine Contraindications decrease diclofenac dosage dose drug duloxetine efficacy enzyme epidural excreted extended-release fentanyl fibers Figure gabapentin gastrointestinal hepatic hydrocodone hydromorphone hyperalgesia ibuprofen increased infusion inhibition inhibitors injection intrathecal intravenous ketamine ketorolac lidocaine medications meperidine metabolism metabolites methadone mg/day mg/kg morphine muscle nausea nerve neuraxial neurons neuropathic pain NMDA receptor nociceptive nociceptors NSAIDs onset opioid analgesic opioid receptors oral oxycodone oxymorphone pain management pain relief parecoxib parenteral pathways patients peripheral pharmacokinetics placebo plasma post-operative pain pregabalin reduced release renal respiratory depression result risk sedation serotonin side effects sodium spinal cord studies surgery syndrome tablets tapentadol therapy tion tissue tolerance toxicity tramadol transdermal treatment trials vomiting