Advances in Clinical Chemistry, Volume 40

Front Cover
Gregory S. Makowski
Gulf Professional Publishing, Dec 12, 2005 - Science - 424 pages
Volume forty in the internationally acclaimed Advances in Clinical Chemistry, contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting edge microarray technology. In keeping with the tradition of the series, this volume emphasizes novel laboratory advances with application not only to both clinical laboratory diagnostics, but as well as practical basic science studies.

This volume of Advances in Clinical Chemistry is an indispensable resource and practical guide for twenty-first century practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.

*Addresses biomarkers in heart disease and breast cancer
*Presents the latest advances in real-time PCR with regard to clinical laboratory diagnostics
*Written by international leaders in the field of clinical chemistry
 

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Contents

1 Abstract
xi
3 Commercially Available Assays for BNP and NT proBNP
7
4 BNP and NTproBNP as Markers of Heart Disease
10
5 Conclusions
24
References
25
1 Abstract
36
3 Oncosis
37
4 Apoptosis
48
5 Dicarbonyl Compounds
190
6 AGE Peptides
195
7 Trends to Be Expected
211
Concept Variations and Data Analysis
219
4 Real Time PCR Platforms
226
5 Signal Detection Formats
227
6 Design of Real Time PCR Assays
231
7 Execution of RealTime PCR Assays
236

5 Autophagy and Autophagic Cell Death
62
6 Cell Death in Diseased Human Hearts
77
7 Concluding Remarks
81
References
83
1 Abstract
98
4 NonFDAApproved Biomarkers Currently Used in a Research Orientation
108
5 Emerging Biomarkers
111
References
116
1 Abstract
125
3 Standard Serological Repertoire
127
4 Current Clinical Applications
137
5 Pitfalls in the Serological Diagnosis
139
6 Autoantibodies Under Investigation
141
7 Supplemental Autoantibodies
146
8 Summary
149
References
150
1 Abstract
163
2 Introduction
164
3 MALDI Mass Spectrometry of In Vitro Glycated Proteins
166
4 MALDI Mass Spectrometry of In Vivo Glycated Proteins
174
8 Applications of Real Time PCR
238
9 Conclusions
245
References
247
1 Abstract
259
3 Stages of Lung Development
261
4 Transcriptional Control of Lung Development
263
5 Growth Factors and Lung Development
266
6 Summary
295
Abbreviations
296
References
297
1 Abstract
316
3 Male Reproductive System
317
4 Gonadotropin Assays
323
5 Fertilization
325
6 Male Factor Subfertility
327
7 Semen Analysis
338
8 Environment and Male Reproductive Functions
348
9 Conclusions
351
Index
363
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About the author (2005)

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

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