Oncogenes and Growth Control
Patricia Kahn, Thomas Graf
Springer Berlin Heidelberg, Oct 1, 1986 - Medical - 369 pages
How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.
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A Role for ProtoOncogenes in Differentiation?
The GranulocyteMacrophage ColonyStimulating Factors
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3T3 cells Acad Sci USA adenovirus amino acid antigen autocrine avian Berlin Heidelberg 1986 binding Biol Chem c-abl c-fms c-fos c-myc c-Src C-terminal Cancer cDNA cell lines cell types cellular chromosome cloned culture cytoplasmic differentiation domain EGF receptor EMBO embryo encoding enhancer epidermal growth factor exon fibroblasts function gene expression gene product globin gene Graf Growth Control Edited growth factor receptor homology hormone human induce inositol interaction intracellular kinase activity leukemia levels mechanism methylation mitogenic Mol Cell Biol molecular molecules mouse mRNA murine mutations Natl Acad Sci normal oncogene Oncogenes and Growth pathway PDGF phenotype phosphorylation platelet-derived growth factor polyoma precursor Proc Natl Acad proliferation promoter protein kinase proto-oncogene ras genes ras proteins region regulation regulatory role sarcoma virus sequences signal specific stimulation suggests synthesis tion tissues transcription transformed cells transgenic mice translocation tumor tyrosine kinase v-abl v-erbB v-src viral vitro vivo yeast