Free radicals in biology and medicine
Clarendon Press, 1985 - Language Arts & Disciplines - 346 pages
"This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.
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Oxygen is poisonousan introduction to oxygen toxicity
The chemistry of oxygen radicals and other oxygenderived
a radical chain reaction
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anaerobes animals antioxidants aqueous solution assay atom bacteria Biochem biological bleomycin blood cancer carbon carcinogens catalase catalase activity causes cells Chapter chelating chemical chlorophyll chloroplasts coli complex compounds contain copper CuZnSOD cytochrome P450 damage decreased dehydrogenase detected disease dismutation double bonds drugs effects electrons enzyme erythrocytes ethanol example exposure fatty acids Fe(III Fe2+ FeSOD formation free radicals glutathione peroxidase GSSG haem haemoglobin human hydrogen peroxide hydroperoxide hydroxyl radicals inactivated increased inhibit injection ions iron salts lens lipid peroxidation lipoxygenase liver lung macrophages mechanism membrane lipids metabolism microsomal mitochondria MnSOD molecule NADH NADPH neutrophils normal orbitals organic oxidation oxygen radicals oxygen toxicity paraquat phagocytic pigment present produced prostaglandin protect protein radical reactions rate constant rats react reactive reduced reductase scavengers shown singlet oxygen SOD activity species structure substrate superoxide dismutase superoxide radical synthesis Table tumour vitamin vitro vivo xanthine oxidase