Longevity, Senescence, and the Genome
Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging.
To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.
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The Comparative Biology of Senescence
11 The Agenda
12 Definitions and Concepts
13 Sources of Information and Experimental Approaches
14 Mortality Rates and Lifespans
15 Evolution and the Relationships between Reproduction and Senescence
75 Posttranslational Modifications
76 Cell Proliferation and DNA Synthesis
77 Cell Death
78 Memories and Gene Expression
Fidelity in the Maintenance of Genomic DNA and Its Replication during Senescence
82 Somatic Cells and Agerelated Modifications of Genetic Structure
Rapid Senescence and Sudden Death
22 Developmental Determinants of Rapid Senescence
23 Reproductionrelated Rapid Senescence and Sudden Death
24 Virus and Episomeinduced Senescence in Filamentous Fungi
25 Rapid Senescence and Sudden Death of Unknown Origin
Gradual Senescence with Definite Lifespan
32 Clonal Senescence in Ciliates
33 Plants and Invertebrates
34 Fish and Lower Vertebrates
42 Indeterminate Lifespans and Negligible Senescence
43 Finite Lifespans with Negligible Senescence
44 Vegetative Reproduction by Somatic Cell Cloning
45 Summary of Chapters 24
Rates of Living and Dying Correlations of Lifespan with Size Metabolic Rates and Cellular and Biochemical Characteristics
52 Correlations of Body Size and Metabolic Rates
53 Lifespan Size and Metabolism
54 Cellular and Biochemical Correlations with Lifespan
Genetic Influences on Lifespan Mortality Rates and Agerelated Diseases
62 The Nematode Caenorhabditis
64 Fungi and Plants
Genomic Functions during Senescence
Gene Expression and Macromolecular Biosynthesis
73 Differential Gene Expression
74 RNA and Protein Synthesis
83 Cancer and Agerelated Genetic Changes
84 Plasmids and Episomes in Somatic Cells
85 Parental Age and Abnormalities in Gametogenesis Fertility and Development
Developmental Influences on Lifespan and Senescence
93 Developmental Influences on Patterns of Senescence
94 Developmental Determinants of Regeneration and Cell Renewal
Postmaturational Influences on the Phenotypes of Senescence
103 Diet and Caloric Restriction
104 Sex Hormones
105 Stress and Corticosteroids
106 Costs of Reproduction and Accelerated Senescence
107 Immunological Changes and Hormones
How to Measure Influences on Senescence
Phylogeny and Evolutionary Changes in Longevity and Senescence
112 An Outline of Evolution and a Discussion of Early Biochemical and Molecular Changes
113 Examples of Phylogenetic Variations in Senescence and Longevity
114 Factors in the Evolution of Senescence and Longevity
Genomic Mechanisms in the Biology of Extended Time
123 Exogenous Factors Endogenous Factors and Cascades
124 Types of Genetic Influences on the Lifespan
125 Aging in the Biology of Extended Time
abnormalities accumulation adult phase age-related changes age-related increases alleles Alzheimer's disease aneuploidy aphagous blood body brain capacity cause cence chromosome clonal senescence correlations corticosteroids cycle damage death decreased degeneration delayed developmental diapause diet restriction disease Drosophila effects eggs enzymes estrogen evolutionary example factors females fibroblasts Figure Finch fish flies functions genetic genomic genotypes glucose glycation growth hormone humans indicate influence insects iteroparous kidney lampreys larval later ages lesions lipofuscins liver long-lived longevity loss major males mammals maturation maximum lifespan mechanisms metabolism mice molecular months mortality rate mouse MRDT mRNA mutations nematodes neurons occur onset oocytes oogenesis organisms ovarian phenotypes physiological plants populations proliferation protein synthesis rapid senescence rats Redrawn reproductive schedules reproductive senescence rodents rotifers salmon Section selection semelparity senes senescence sexual somatic cells spawning species strains studies survival syndrome teleosts temperature tion tissues total lifespan variations vegetative vegetative reproduction vitro
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