Molecular Mechanisms of AnesthesiaB. Raymond Fink |
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Page 37
... presence of drug are measured 10 min after drug has been applied internally to axons . In the presence of 5 × 10-4 M drug , sodium currents were approximately 68 % of the control in both cases . In C , the dose - response relationship ...
... presence of drug are measured 10 min after drug has been applied internally to axons . In the presence of 5 × 10-4 M drug , sodium currents were approximately 68 % of the control in both cases . In C , the dose - response relationship ...
Page 168
... presence of carbamylcholine . It should be emphasized that this observed high - affinity binding must reflect a property of the desensitized Torpedo postsynaptic membrane . Similar high - affinity binding is observed in the presence of ...
... presence of carbamylcholine . It should be emphasized that this observed high - affinity binding must reflect a property of the desensitized Torpedo postsynaptic membrane . Similar high - affinity binding is observed in the presence of ...
Page 171
... presence of high concentra- tions of proadifen , lidocaine , or 2 - propanol , = eq = K 0.2 . In the presence of H12 - HTX , K1 2.3 . Thus , 2 - propanol , lidocaine , and proadi- fen can increase Keg by as much as a factor of 4.6 ...
... presence of high concentra- tions of proadifen , lidocaine , or 2 - propanol , = eq = K 0.2 . In the presence of H12 - HTX , K1 2.3 . Thus , 2 - propanol , lidocaine , and proadi- fen can increase Keg by as much as a factor of 4.6 ...
Contents
General Perturbations versus Specific Receptors | 1 |
Ionic and Gating | 7 |
Relationship Between Inactivation of Sodium Channels and Block By Quaternary | 17 |
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Common terms and phrases
acetylcholine acid Acta action potential activity adenylate cyclase agonist alcohols alter anesthesia Anesthesiology anesthetic action anesthetic agents anesthetic molecules barbiturates Biochem Biophys block of sodium brane carbamylcholine changes choline cholinergic coefficient concentration conductance constant cortex crease cyclic AMP decrease depolarization depression desensitization drug effect of halothane effects of anesthetics end-plate enflurane enzyme ethanol fluidity function GABA halothane high-affinity hydrophobic inactivation increase incubation inhibition interaction K₁ kinetics lidocaine ligands lipid bilayer local anesthetics measured mepc metabolism mice muscle nerve neuromuscular neurons nitrous oxide observed octanol pentobarbital perturbation Pharmacol phase phospholipid Physiol postsynaptic potency presence pressure reversal procaine Progress in Anesthesiology protein pulse Raven Press receptor response shown sodium channel sodium current solution spin label squid squid giant axons structure studies temperature thetics tion tissue Torpedo toxin binding uptake vesicles volatile anesthetics voltage