Epigenetics

Front Cover
C. David Allis, Thomas Jenuwein, Danny Reinberg
CSHL Press, 2007 - Medical - 502 pages
3 Reviews
The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.
 

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This authors did a great job integrating chronological growth of knowledge from diverse models, about a subject truly still in its early stages. Thanks

Contents

Ch 4 Epigenetics in S cerevisiae
63
Ch 5 PostEffect Variegation Heterochromatin Formation and Gene Silencing in Drosophila
81
S pombe and N crassa
101
Ch 7 Epigenetics of Ciliates
127
Ch 8 RNAi and Heterochromatin Assembly
151
Ch 9 Epigenetic Regulation in Plants
167
Ch 10 Chromatin Modifications and Their Mechanisms of Action
191
Ch 11 Transcriptional Silencing by Polycomb Group Proteins
211
Ch 18 DNA Methylation in Mammals
341
Ch 19 Genomic Imprinting in Mammals
357
Ch 20 Germ Line and Pluripotent Stem Cells
377
Ch 21 Epigenetic Control of Lymphopoiesis
397
Ch 22 Nuclear Transplantation and the Reprogramming of the Genome
415
Ch 23 Epigenetics and Human Disease
435
Ch 24 Epigenetic Determinants of Cancer
457
App 1 WWW Resources
477

Ch 12 Transcriptional Regulation by Trithorax Group Proteins
231
Ch 13 Histone Variants and Epigenetics
249
Ch 14 Epigenetic Regulation of Chromosome Inheritance
265
Ch 15 Epigenetic Regulation of X Chromosomes in C elegans
291
Ch 16 Dosage Compensation in Drosophila
307
Ch 17 Dosage Compensation in Mammals
321
App 2 Histone Modification and References
479
Index
491
Back Cover End Page
503
Back Cover
504
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