Varicella-Zoster Virus: Virology and Clinical Management
The successful development of a VZV vaccine reflects intense research interest in this virus over recent years. This comprehensive account of the biology and clinical features of the varicella-zoster virus, published in association with the VZV Research Foundation, surveys current knowledge of the molecular biology, pathogenesis, and clinical features of VZV as the causative agent of chickenpox and zoster (shingles). The volume covers such topics as viral replication, latency, immune mechanisms, epidemiology and disease manifestations, and complications of varicella and zoster. Also included is detailed information on live attenuated varicella vaccine, treatment strategies, and the management of postherpetic pain in zoster patients. As the most authoritative review and guide to the virus and its diseases, this book will appeal to a wide range of clinicians and investigators, including pediatricians, geriatricians, neurologists, dermatologists, infectious disease specialists, and virologists interested in the herpes viruses.
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acute acyclovir adults antigen antiviral Arvin Asano assay attenuated varicella vaccine Brunell cella chickenpox Clin clinical cutaneous Davison dermatome detected developed diagnosis disease DNA polymerase DNA replication dose encephalitis encoded Enders exposure famciclovir fetal fluid Forghani foscarnet gabapentin ganglia gene genome Gershon Gilden glycoprotein Grose herpes simplex virus herpes zoster herpes zoster ophthalmicus herpesviruses Hope-Simpson human immune response immunocompetent immunocompromised immunocompromised patients incidence infants infected cells inoculation isolation kinase Kinchington LaRussa latency lesions lymphocytes mutants neurologic neurons occur onset oral acyclovir pain Pediatrics postherpetic neuralgia pregnancy rash reactivation reported risk sequence serologic serum skin specific Straus studies susceptible syndrome Takahashi therapy tion tissue titers transcription transplant trigeminal valaciclovir varicella vaccine varicella zoster virus varicella-zoster virus varicella-zoster virus infection virions Virol Virology viruses vitro VZIG VZV antibody VZV antigen VZV DNA VZV infection VZV proteins VZV-specific zoster virus