Mouse Models of Human Cancer

Front Cover
Eric C. Holland
Wiley, Aug 27, 2004 - Science - 504 pages
Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments.

Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text:

  • Presents real experimental data
  • Describes organ site-specific mouse models
  • Clearly identifies suitable models for further drug testing
  • Critically analyzes current methodologies and their limitations
  • Features numerous recognizable expert contributors
  • Lists key Web sites, reagents, and companies

From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions.

Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

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Contents

Dalit Barkan Cristina Montagna
103
Prostate Cancer
133
Preservation Genotyping and Drug
171
Copyright

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Mouse Models of Human Cancer
Eric C. Holland
Limited preview - 2004

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Acad Sci USA activity adenocarcinoma agents allele analysis angiogenesis animals antigen apoptosis B-cell Biol blood brain tumors breast cancer c-myc cancer cells cancer modifiers Cancer Res carcinogenesis cellular chromosome clinical detection differentiation disease drug effects embryos endothelial epithelium gene expression genome gland gliomas growth factor hematopoietic histologic human cancers hyperplasia identified imaging immune Immunol inactivation inbred induced infection inhibition inhibitors interactions kinase lesions loxP luciferase lymphoid lymphoma malignant mammary tumor mapping marker melanoma metastasis metastatic mice Models of Human molecular molecules mouse models murine mutations Nat Genet Natl Acad Sci neoplasms oncogene ovarian cancer overexpression pathology pathway phenotype Proc Natl Acad promoter prostate cancer protein PTEN receptor recombinase recombination retroviral sarcoma signaling specific strains studies target therapeutic therapy tion tissue transcription transgenic transgenic mice treatment tumor cells tumor suppressor tumor suppressor genes tumorigenesis vascular vector viral virus vivo

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About the author (2004)

Eric Holland received his Ph.D. from the University of Chicago in 1985 and M.D. from Stanford University in 1990.  He completed his residency in neurosurgery at UCLA and did postdoctoral work at Stanford and the NIH.  He holds appointments at Memorial Sloan-Kettering Cancer Center and Cornell University.  He is a clinically active neurosurgeon and heads a laboratory at the Sloan-Kettering Institute focused primarily on understanding the molecular mechanisms underlying the pathogenesis of CNS tumors and in modeling these cancers in the mouse. Dr. Holland is the recipient of the Searle Scholars Award, the American Brain Tumor Association Research Award, the Peter Steck Memorial Award, the Bressler Scholars Award and the Seroussi Award.  He has served on the NIH Brain Tumor Process Review Group, is a member of the Mouse Models of Human Cancer Consortium and is the Principal Investigator of the Brain Tumor SPORE program at MSKCC

Bibliographic information

TitleMouse Models of Human Cancer
EditorEric C. Holland
Editionillustrated
PublisherWiley, 2004
Original fromthe University of Michigan
DigitizedAug 5, 2008
ISBN047144460X, 9780471444602
Length504 pages
Subjects ›  › 

Medical / General
Science / Life Sciences / Genetics & Genomics
  
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