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animal facility animal house animal rooms animal technicians autoclaving barrier Bibliography bottle bred breeding centre breeding unit cages carried cent Chapter cleaning commercial breeders considerable cost culling demand depend diet disease dogs and cats Drepper economic environment equipment ethylene oxide experience experimental animal female foster dam genes genetic genotype germfree guinea-pigs homozygosity homozygous husbandry hysterectomy ICLA inbred strains infection isolator laboratory animal science Laboratory Animals Centre Lane-Petter large numbers less litter maintenance male material mating ment method mice microorganisms mouse necessary number of animals nutritional oestrus operation organisms outbred pathogen pellets period population possible practical primary type colony problem production unit purposes rabbits racks rats and mice requirements Research Defence Society result rodents selection small rodents species staff standard sterilization supply techniques temperature tion usage ventilation vitamin weaning white colony