Drug Action in the Central Nervous System

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Oxford University Press, 1998 - Central nervous system - 416 pages
Pharmacodynamics--the mechanisms and pathways through which drugs influence living organisms--is the primary subject of Drug Action in the Central Nervous System. Many aspects of current working theories of epilepsy, depression, anxiety, schizophrenia, Parkinson's disease and other
neurological and psychiatric disorders are based on studies of the pharmacodynamics of drug action in the central nervous system. The knowledge acquired from these studies can be successfully applied to the treatment of neurological and psychiatric disorders as well.
The first three chapters of this book provide an overview of brain function and the basic principles of drug delivery and receptor function. Subsequent chapters analyze in full detail the pharmacodynamics of the centrally-acting drugs, including analgesics, anesthetics, muscle relaxers, migraine
drugs, antiepileptics, antidepressants, antipsychotics, and sedative-hypnotics. Each of these chapters starts with a brief survey of the neurobiology of the systems affected by the drug class under discussion, followed by a detailed description of the mechanism of action, major side effects, and
relevant pharmacokinetics of the drug class. The book also details the effects of street drugs on the nervous system. A chapter-by-chapter drug list is included in the appendix. Throughout the text, figures illustrate key concepts that do not yield readily to verbal description. Tables summarize
DSM-IV criteria and list the therapeutic and side effects of the various drug classes.

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Contents

Introduction
1
The Delivery of Drugs to the CNS
19
Drugs and Receptors
47
Copyright

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About the author (1998)

About the authorPaul M. Carvey, Ph.D., is Professor of Pharmacology and Neurological Sciences and Chairman of the Department of Pharmacology at Rush University in Chicago. He has published over sixty articles on the mechanisms by which drugs affect the central nervous system, and directs an active research programfocusing on Parkinson's disease.

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