Liver Immunology: Principles and Practice
Springer Science & Business Media, Jan 24, 2008 - Medical - 501 pages
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided. Liver Immunology: Principles and Practice covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells. This volume will become a must-read for clinicians, investigators and students, novice and expert alike.
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acid adaptive immune alcoholic hepatitis allograft antibodies antigen APCs apoptosis associated autoantibodies autoimmune diseases autoimmune hepatitis autoimmune liver disease bile duct CD4+ CD8+ T cells cell activation cellular chemokines chronic hepatitis Clin clinical cytokines cytotoxic dendritic cells detected diagnosis drug effector endothelial cells epitopes expression fibrosis function Gastroenterol Gastroenterology gene genetic HCV infection hepatitis C virus hepatocellular hepatocytes Hepatol Hepatology hepatotoxicity histological human immune response immune system Immunol immunological immunosuppressive induced inflammation inflammatory inhibition innate immune interferon intrahepatic Kupffer cells leukocytes ligand liver injury liver transplantation LSECs lymphocytes macrophages mechanisms mediated metabolism MHC class mice molecules natural killer NK cells pathogenesis patients peptides portal primary biliary cirrhosis primary sclerosing cholangitis proteins receptor recurrence rejection role serum signal sinusoidal specific stellate cells studies syndrome T-cell T-cell responses target therapy tissue tolerance treatment vaccine viral virus infection