The Role of Prostaglandins in Mouse Skin Tumor Promotion and the Tumor Promoting Phorbol Ester Receptor Protein: From Its Discovery to Its Role in the Physiology of Cell Membranes |
Contents
Effects of phorbol ester tumor promoters | 4 |
Inhibition of tumor promotion | 7 |
A direct approach to the study of tumor | 13 |
5 other sections not shown
Common terms and phrases
³H-TPA 3H]TPA binding acetate acetone acid action added addition agents amount anti-inflammatory apparent applied Ashendel assay Biochem biological Biophys bound Boutwell buffer CaCl2 calcium Cancer Res Carcinogenesis cells cellular CHAPS Chart chemicals chromatography cold acetone column compounds concentration correlated dependent described detected detergent determined diester direct doses drugs effect eluted epidermal prostaglandin extraction filtration fractions function histone homogenizer hyperplasia included increased increased epidermal indicated induction inhibition inhibitor involved irritants isolated levels lipid measured mechanism membrane method mice mixture molecular mouse brain mouse epidermis mouse skin mouse skin tumor Nature PGF levels phenyl agarose phorbol esters phosphate phosphatidylserine phospholipid polypeptide possible preparations present prostaglandin levels protein kinase activity purified reduced reported response role similar single skin tumor promotion Slaga solubilized specific binding standard Stimulation structure Studies synthesis Table tissues TPA binding activity TPA receptor treatment tumor promotion washed