I. Introduction Parvoviruses belong to the large group of viral agents of which virologists have become aware by chance in many biological materials due to the availabil ity of more sensitive isolation techniques and the extensive use of the electron microscope. In general, many of these viruses lacked the stimulating background of an infectious disease and, therefore, have fallen into oblivion already soon after discovery. In case of parvoviruses, however, interest has been maintained because of the circumstances under which most of them were isolated. A great number of parvoviruses has been recovered from tissues of tumor bearing animals, from cell-free filtrates of tumors, or from stable cell lines of tumor origin. These observations necessarily suggested the newly isolated viral agents of playing an important, yet unknown role in the induction and develop ment of cancer. On the other hand, further parvoviruses were found constantly associated with adenoviruses. It was the experimental analysis of the multiplica tion behaviour which then revealed that the association between parvoviruses and tumors or parvoviruses and adenoviruses originates from the basis of a cer tain genetic defectiveness. For some members of the group this may be overcome by cellular helper effects in rapidly growing tissues, for several others, however, by biochemical events in the simultaneously occurring replication of an adeno virus only. Additional points of view in favour of parvovirus research have arisen from experimental animal studies.
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b Structural Proteins
e Differences in Antigenic Composition between Various Virus Strains
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acridine orange adenovirus agglutination animals antibodies antigen ataxia BACHMANN bovine parvovirus buoyant density capsids CARTWRIGHT cats cell cultures cell lines cellular cent cerebellar characteristics contain coworkers CsCl daltons disease double-stranded electron microscopy embryonic erythrocytes evidence experimental feline panleukopenia feline panleukopenia virus FPV/MEV g/ml GAUTSCHI gradient guinea pig H-1 virus HALLAUER hamster-osteolytic agents hamster-osteolytic viruses hamsters hemagglutinating hepatitis HI-antibodies hours p.i. immunity INABA inclusion bodies infected cells infectious virions inoculation intranuclear inclusions isolated JOHNSON KBSH kidney cells KILHAM KILHAM and MARGOLIS kittens KRONAUER LuIII LuIII-virus MAYR mice mink enteritis minute virus molecular weight molecules monkey monolayers mouse neutralizing newborn hamsters nucleic acid observed pathogenicity polypeptide porcine porcine parvovirus present protein rat virus recovered RV and H-1 sedimentation sera serologic SIEGL STORz and BATES studies suggested susceptible synthesis tested tissue cultures titers TOOLAN viral DNA virions virus multiplication virus particles virus strains